Recombinant Salmonella typhimurium Flagellin is produced by our E.coli expression system and the target gene encoding Met1-Arg495 is expressed.
Recombinant Salmonella Typhimurium Flagellin
SKU: CR91-10ug
$48.00Price
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Shipping Information
$48 Standard Overnight flat rate for products shipped in room temperature within the United States.
Additional $27 Ice Packs shipment fee is required for liquid proteins.
Please contact us to order for international shipments.
Endotoxin
Less than 0.1 EU/ug
Accession Number
P06179
Species
Salmonella typhimurium
Expression System
E.coli
Target Sequence
Met1-Arg495
Tag
None
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Packaging
Ambient
Background
Flagellin is the major structural protein monomer of bacterial flagella. Flagellin through binding to its receptor and activation of antigen presenting cells stimulates the innate and adaptive immune responses. Flagellin is used as an effective systemic or mucosal adjuvant to stimulate the immune system. Flagellin is an agonist of Toll-like receptor 5 (TLR5), a pattern recognition receptor (PRR) of the innate immune system expressed on the basolateral surface of intestinal epithelial cells and on the surface of a subset of intestinal dendritic cells. Flagellin is delivered into the cytosol of macrophages by the T3SS-1 of serotype Typhimurium, where it activates the cytosolic interleukin-1 (IL-1) converting enzyme-protease activating factor (IPAF), a nucleotide-binding and oligomerization domain-like receptor (NLR) of the innate immunesystem. Recognition of flagellin by IPAF leads to activation of the inflammasome, followed by proteolytic activation of IL-1 and IL-18.
Purity
>95% measured by SEC-HPLC
Flagellin; Phase 1-I flagellin; fliC; flaF; hag
Alternative Names
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Citation
NA
Activity
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