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Recombinant Rat C-C Motif Chemokine 5/CCL5 (N-6His)
Recombinant Rat C-C motif chemokine 5 is produced by our E.coli expression system and the target gene encoding Ser25-Ser92 is expressed with a 6His tag at the N-terminus. Bon Opus Cat. #CE79

Recombinant Rat C-C Motif Chemokine 5/CCL5 (N-6His)

SKU: CE79-10ug
$95.00Price
Quantity
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Endotoxin
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Accession Number
P50231
Species
Rat
Expression System
E.coli
Target Sequence
Ser25-Ser92
Tag
N-His
Formulation
Lyophilized from a 0.2 um filtered solution of 20mM PB, 500mM NaCl, 2mM EDTA, pH 7.4
.
Packaging
Ambient
Background
C-C motif chemokine 5(CCL5) is a β-chemokine that plays a primary role in the inflammatory immune response by means of its ability to attract and activate leukocytes. CCL5 is secreted by many cell types at inflammatory sites, and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5. Inflammatory responses can be impaired by the sequestration of CCL5 by the cytomegalovirus protein US28. Oligomerization of CCL5 on glycosaminoglycans is required for CCR1mediated leukocyte adhesion and activation as well as CCL5’s interaction with the chemokine CXCL4/PF4.The deposition of CCL5 on activated vascular endothelial cells is crucial for monocyte adhesion to damaged vasculature, but CCL5 oligomerization is not required for the extravasation of adherent leukocytes.CCL5 is upregulated in breast cancer and promotes tumor progression through the attraction of proinflammatory macrophages in addition to its actions on tumor cells, stromal cells, and the vasculature.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
C-C motif chemokine 5; SIS-delta; Small-inducible cytokine A5; T-cell-specific protein RANTES; Ccl5; Scya5
Alternative Names
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Citation
NA
Activity
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