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Recombinant Mouse Tissue Factor (C-6His)

Recombinant Mouse Tissue Factor (C-6His)

SKU: CU70-10ug
$158.00Price
Recombinant Mouse Tissue factor is produced by our Mammalian expression system and the target gene encoding Ala29-Glu251 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CU70
Endotoxin
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Accession Number
P20352
Species
Mouse
Expression System
Human Cells
Target Sequence
Ala29-Glu251
Tag
C-His
Formulation
Lyophilized from a 0.2 um filtered solution of 20mM Tris-HCl, 150mM NaCl, 0.05%Brij35, pH 7.5.
Packaging
Ambient
Background
Tissue Factor, also known as thromboplastin and CD142, belongs to the tissue factor family which conteins 294 amino acid (aa). Mouse TF consists of a signal peptide (residues 1-28) and the mature chain (residues 29-294). It is a single-pass type I membrane protein that expressed in the liver oscillates in a circadian manner. Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Tissue factor; TF; Coagulation factor III;
Alternative Names
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Citation
NA
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