Recombinant Mouse SLAM Family Member 5/SLAMF5/CD84(C-6His)

Recombinant Mouse SLAM Family Member 5/SLAMF5/CD84(C-6His)

SKU: CK72-10ug
Recombinant Mouse SLAMF5 is produced by our Mammalian expression system and the target gene encoding Lys22-Pro223 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CK72
  • Accession Number

  • Background

    CD84, also called SLAMF5, is a member of the CD2 subgroup of the immunoglobulin receptor superfamily. Members of this CD2 subgroup mediate signal transduction through the interaction of its immunoreceptor tyrosine-based switch motifs (ITSM) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. CD84 expression has been documented on several hematopoietic cell types, including monocytes, macrophages, dendritic cells, B lymphocytes, and platelets. Activation of cell surface CD84 initiates a signaling cascade involving its intra-cytoplasmic tyrosine residues that results in Bcl-2 upregulation, which in turn enhances cell survival. Either immunoneutralization or blockade of CD84 with a CD84 extracellular domain protein fragment induces cell death in vitro and in vivo.
  • Expression

    Human Cells
  • Packaging

  • Formulation

    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
  • ALTnames

    SLAM family member 5, Cd84, Leukocyte differentiation antigen CD84, Signaling lymphocytic activation molecule 5, CD84, Ly-9B, SLAMF5, CD84 antigen, CD84 molecule, SLAM family member 5

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