Recombinant Mouse Serpin D1/Heparin Cofactor II/HCF2 (C-6His)
Recombinant Mouse Serpin D1/Heparin cofactor 2/HCF2 is produced by our Mammalian expression system and the target gene encoding Glu24-Ser478 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CK98
BackgroundSerpinD1, also known as heparin cofactor II(HC-II), is a member of Serpin superfamily of the serine proteinase inhibitors. It is a single chain glycoprotein with a size of 66.5 kDa and is secreted from hepatocytes. HC-II acts as a thrombin inhibitor in the coagulation cascade, in a glycosaminoglycan-dependent pathway using the release of a sequestered hirudin-like N-terminal tail for interaction with thrombin. This serpin belongs to multiple member group V2 of vertebrate serpin classification. It has been suggested that HC-II is a predictor of decreased atherosclerosis in the elderly and protective against atherosclerosis in mice. HCII can used as a predictive biomarker and therapeutic target for atherosclerosis.
FormulationLyophilized from a 0.2 μm filtered solution of 20mM HEPES,150mM NaCl,pH7.4.
ALTnamesHeparin cofactor 2, Heparin cofactor II, HC-II, Protease inhibitor leuserpin-2, Serpin D1