Recombinant Mouse Pulmonary Surfactant-associated Protein D/SP-D (C-6His)
Recombinant Mouse Pulmonary Surfactant-associated Protein D is produced by our Mammalian expression system and the target gene encoding Ala20-Phe374 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CB54
BackgroundSP-D (surfactant protein D) is a 43 kDa member of the collectin family of innate immune modulators. Mouse SP-D cDNA encodes a 19 aa signal sequence and a 355 aa mature region with a 25 aa N-terminal linking region, a 177 aa hydroxyproline and hydroxylysine collagen-like domain, a 46 aa coiled-coil segment, and a 106 aa, C-terminal collectin-like C-type lectin domain-.SP-D is usually found as a glycosylated, disulfide-linked 150 kDa alpha-helical coiled-coil trimer with a “head” of three symmetrical CRDs . SP-D also binds SIRP alpha and the calreticulin/CD91 complex on macrophages.
FormulationLyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
ALTnamesCOLEC7collectin-7; Collectin 7; Lung surfactant protein D; PSPD; SFTP4; SFTP4pulmonary surfactant-associated protein D; SFTPD; SPD; SP-D; SP-Dpulmonary surfactant apoprotein; surfactant protein D; surfactant, pulmonary-associated protein D; surfactant-associated protein, pulmonary 4