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Recombinant Mouse OX40/TNFRSF4/CD134 (N-Fc)
Recombinant Mouse OX40 is produced by our Mammalian expression system and the target gene encoding Val20-Pro211 is expressed with a Fc tag at the N-terminus. Bon Opus Cat. #CK53

Recombinant Mouse OX40/TNFRSF4/CD134 (N-Fc)

SKU: CK53-10ug
$100.00Price
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Endotoxin
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Accession Number
P47741
Species
Mouse
Expression System
Human Cells
Target Sequence
Val20-Pro211
Tag
N-Fc
Formulation
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Packaging
Ambient
Background
OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Tumor necrosis factor receptor superfamily member 4;Tnfrsf4;OX40;CD134;Txgp1
Alternative Names
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Citation
NA
Activity
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