Recombinant Mouse Neuropilin-1 is produced by our Mammalian expression system and the target gene encoding Phe22-Pro856 is expressed with a 6His tag at the C-terminus.
Recombinant Mouse Neuropilin-1/NRP1 (C-6His)
SKU: C11R-10ug
$79.00Price
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Shipping Information
$48 Standard Overnight flat rate for products shipped in room temperature within the United States.
Additional $27 Ice Packs shipment fee is required for liquid proteins.
Please contact us to order for international shipments.
Endotoxin
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Accession Number
P97333
Species
Mouse
Expression System
Human Cells
Target Sequence
Phe22-Pro856
Tag
C-6His
Formulation
Lyophilized from a 0.2 um filtered solution of PBS,pH7.4.
Packaging
Ambient
Background
Neuropilin-1 (Npn-1, previously neuropilin; also CD304) is a 130 - 140 kDa type I transmembrane (TM) glycoprotein that regulates axon guidance and angiogenesis. Two homologues, Neuropilin-1 and Neuropilin-2, are identified. Neuropilin-1 binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. NRP1 expression is regulated in EC by tumor necrosis factor-alpha, the transcription factors dHAND and Ets-1, and vascular injury. NRP1 upregulation is positively correlated with the progression of various tumors.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
CD304; NRP1; NRPNP1; VEGF165R; BDCA4
Alternative Names
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Citation
NA
Activity
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