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Recombinant Mouse Legumain/Asparaginyl Endopeptidase is produced by our Mammalian expression system and the target gene encoding Val18-Tyr435 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CJ83

Recombinant Mouse Legumain/Asparaginyl Endopeptidase (C-6His)

SKU: CJ83-10ug
$158.00Price
Quantity
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$48 Standard Overnight flat rate for products shipped in room temperature within the United States.

 

Additional $27 Ice Packs shipment fee is required for liquid proteins.

 

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Endotoxin
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Accession Number
O89017
Species
Mouse
Expression System
Human Cells
Target Sequence
Val18-Tyr435
Tag
C-His
Formulation
Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 150mM NaCl, 20% Glycerol, pH 8.0.
Packaging
Dry Ice/ice packs
Background
Mouse Legumain,also known as LGMN, is a cysteine protease belonging to peptidase family C13 and is expressed in kidney and placenta abundantly. LGMN has a strict specificity for hydrolysis of asparaginyl bonds. It can also cleave aspartyl bonds slowly, especially under acidic conditions. The mammalian legumain is involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. It plays a role in the regulation of cell proliferation via its role in EGFR degradation. Legumain deficiency causes the accumulation of pro-Cathepsins B, H and L, another group of lysosomal cysteine proteases. Overexpression of Legumain in tumors is significant for invasion/metastasis. Mammalian legumain is inhibited by iodoacetamide and maleimides. Legumain activation appears to be autocatalytic and can be triggered by acidic pH.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Legumain;Lgmn;Asparaginyl endopeptidase;Protease cysteine 1;Prsc1
Alternative Names
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Citation
NA
Activity
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