Recombinant Mouse Kin of IRRE-like protein 1 is produced by our Mammalian expression system and the target gene encoding Leu48-Leu525 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CB08

Recombinant Mouse Kirrel1/Neph1(C-6His)

Name: Recombinant Mouse Kirrel1/Neph1(C-6His)
SKU: CB08-10ug
Price: 74 USD
Availability: InStock

SKU: CB08-10ug

$74.00

Size

Quantity

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Shipping Information

$48 Standard Overnight flat rate for products shipped in room temperature within the United States.

Additional $27 Ice Packs shipment fee is required for liquid proteins.

Please contact us to order for international shipments.

Certificate of Analysis

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Endotoxin

Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

Accession Number

Q80W68

Species

Mouse

Expression System

Human Cells

Target Sequence

Leu48-Leu525

C-His

Formulation

Lyophilized from a 0.2 um filtered solution of PBS,pH7.4.

Packaging

Ambient

Background

Kin of irregular chiasm-like protein 1(Kirrel1), also known as Nephrin-like protein 1(Neph1), belongs to the immunoglobulin superfamily. Kirrel1 plays a significant role in the normal development and function of the glomerular permeability. It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. The knockout of this gene could result in perinatal lethality accompanied by proteinuria, and effacement of glomerular podocytes. Kirrel1 is abundantly expressed in kidney and specifically expressed in podocytes of kidney glomeruli. Its’ subunit interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus) and interacts with NPHS1/nephrin (via the Ig-like domains). This interaction is dependent on KIRREL glycosylation. Kirrel1 also interacts when tyrosine-phosphorylated with GRB2.