Recombinant Mouse Kallikrein 1/mGK-6 (C-6His)
Recombinant Mouse Kallikrein-1 is produced by our Mammalian expression system and the target gene encoding Pro19-Asp261 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CU31
BackgroundKallikreins belongs to the family of trypsin-like serine proteases, many of which are associated with a variety of cancers. Kallikrein 1 (KLK1) is also known as tissue kallikrein and urinary kallikrein. KLK1 is synthesized as a 261 amino acid (aa) protein that contains a 18 aa signal peptide and a 241 aa proprotein. An important physiological function of KLK1 cleaves Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Kinins regulate vasodilation, blood pressure reduction, smooth muscle relaxation and contraction, pain induction and inflammation.
FormulationLyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH7.5.
ALTnamesGlandular kallikrein K1; KAL-B; Renal kallikrein; Tissue kallikrein-6; mGK-6