Recombinant Mouse Interleukin-12/IL-12 (C-His)
Recombinant Mouse Interleukin-12 is produced by Human 293 Cells. The target gene encoding M23-S335; R23-A125 is expressed with a 8His tag at the C terminus.
ExpressionHuman 293 Cells
BackgroundInterleukin-12 (IL-12) is a heterodimeric pleiotropic cytokine that consists of IL12A (p35) and IL12B (p40) subunits. IL?12 is expressed by macrophages and B lymphocytes and act as a growth factor for activated T and NK cells, help enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Studies have shown that IL?12 is a key mediator of cellular-immunity and induces the differentiation of Th1 cells from precursor T helper cells. Based on its activities, it has been predicted that IL?12 may have therapeutic potential as a vaccine adjuvant that promotes cellular-immunity and as an anti-tumor and anti-viral agent.
FormulationLyophilized frum a 0.2 um filtered solution of PBS, pH7.4
ALTnamesIL-12; Interleukin 12; Interleukin-12 subunit alpha;IL-12A;Cytotoxic lymphocyte maturation factor35 kDa subunit; CLMF p35;IL-12 subunit p35; Interleukin-12 subunit beta; IL-12B; Cytotoxiclymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40