BackgroundMouse β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival.
FormulationLyophilized from a 0.2 μm filtered solution of 20mM Tris,200mM NaCl,pH8.0.
ALTnamesBeta-Nerve Growth Factor, Beta-NGF, NGF, NGFB