Recombinant Human ZW10 Interactor/ZWINT (N-His)
Recombinant Human ZWINT is produced by E. coli. The target gene encoding M1-P277 is expressed with a 6His tag at the N terminus.
BackgroundZW10 Interactor is localized to the kinetochores from late Prophase to Anaphase and has a uniform distribution in the cytoplasm of Interphase cells. ZWINT interacts ZW10, MIS12 and NDC80 subunit of the NDC80 complex specifically during mitosis. ZWINT is a part of the MIS12 complex which is required for kinetochore formation and spindle checkpoint activity. In addition, ZWINT is required to target ZW10 to the kinetochore at prometaphase.
FormulationLyophilized frum a 0.2 um filtered solution of 2umM PB, 15umM NaCl, pH 7.2
ZW10 Interactor; ZW10‐Interacting Protein 1; Zwint‐1; ZWINT