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Recombinant Human Urokinase-Type Plasminogen Activator/uPA/PLAU (C-6His)

Recombinant Human Urokinase-Type Plasminogen Activator/uPA/PLAU (C-6His)

SKU: C393-10ug
$158.00Price
Recombinant Human Urokinase is produced by our Mammalian expression system and the target gene encoding Ser21-Leu431 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #C393
Endotoxin
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Accession Number
P00749
Species
Human
Expression System
Human Cells
Target Sequence
Ser21-Leu431
Tag
C-His
Formulation
Supplied as a 0.2 um filtered solution of 20mM HEPES, 2mM CaCl2, 10% Glycerol, pH 7.4.
Packaging
Dry ice/ice packs
Background
Recombinant Human Urokinase-Type Plasminogen Activator is a serine protease, which specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. Urokinase-Type Plasminogen Activator is a potent marker of invasion and metastasis in many human cancers associated with breast, colon, stomach, bladder, brain, ovary and endometrium. Human Urokinase-Type Plasminogen Activator is initially synthesized as 431 amino acid precursor with a N-terminal signal peptide residues. The single chain molecule is processed into a disulfide-linked two-chain molecule. There exists two forms A chain, the long A chain contains an EGF-like domain that is responsible for binding of the uPA receptor. The B chain corresponds to the catalytic domain.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Urokinase-Type Plasminogen Activator; U-Plasminogen Activator; uPA; PLAU
Alternative Names
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Citation
NA
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