Recombinant Human USP14 is produced by our E.coli expression system and the target gene encoding Asp91-Gln494 is expressed with a 6His tag at the N-terminus. Bon Opus Cat. #C191

Recombinant Human Ubiquitin Carboxyl-Terminal Hydrolase 14/USP14 (N-6His)

Name: Recombinant Human Ubiquitin Carboxyl-Terminal Hydrolase 14/USP14 (N-6His)
SKU: C191-10ug

SKU: C191-10ug

$74.00

Quantity

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Phone: 800-943-6396 ext#1

Email: orders@bonopusbio.com

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Shipping Information

$48 Standard Overnight flat rate for products shipped in room temperature within the United States.

Additional $27 Ice Packs shipment fee is required for liquid proteins.

Please contact us to order for international shipments.

Certificate of Analysis

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Endotoxin

Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

Accession Number

P54578

Species

Human

Expression System

E.coli

Target Sequence

Asp91-Gln494

N-His

Formulation

Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 100mM NaCl, 20% Glycerol, pH 8.0.

Packaging

Dry ice/ice packs

Background

Ubiquitin Carboxyl-Terminal Hydrolase 14 (USP14) belongs to the ubiquitin-specific processing (USP) family which is a deubiquitinating enzyme (DUB) with His and Cys domains. USP14 located in the cytoplasm is a proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. USP14 acts also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. In addition, USP14 is indispensable for synaptic development and function at neuromuscular junctions, required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis.