Recombinant Human Tumor Necrosis Factor Receptor Superfamily Member 4 (C-Fc-Avi)
Recombinant Human TNF Receptor Superfamily Member 4 is produced by our Mammalian expression system and the target gene encoding Leu29-Ala216 is expressed with a Fc & Avi tag at the C-terminus. Bon Opus Cat. #CU04
BackgroundOX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.
FormulationLyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
ALTnamesTumor necrosis factor receptor superfamily member 4; ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; CD134; TNFRSF4; TXGP1L