Recombinant Human Tumor Necrosis Factor Receptor II/TNFRSF1B/CD120b (C-6His)
Recombinant Human Tumor Necrosis Factor Receptor II is produced by our Mammalian expression system and the target gene encoding Leu23-Asp257 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CI39
BackgroundTumor necrosis factor receptor superfamily member 1B is a 461 amino acids protein that belongs to the TNFR (tumor necrosis factor receptor) superfamily characterized by cysteine-rich extracellular domains. It contains 4 TNFR-Cys repeats. TNFRII is expressed in fetal brain. TNFRII is strongly expressed at the cartilage-pannus junction, and plays a major role in a subset of families with multiple cases of rheumatoid arthritis (RA). This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
FormulationLyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
ALTnamesTumor necrosis factor receptor superfamily member 1B，Tumor necrosis factor receptor 2，Tumor necrosis factor receptor type II，p75，p80 TNF-alpha receptor，TBP-2，TBPII，TNFRSF1B，TNFBR, TNFR2