Recombinant Human Tumor Necrosis Factor Receptor I is produced by our Mammalian expression system and the target gene encoding Leu30-Thr211 is expressed with a Fc tag at the C-terminus. Bon Opus Cat. #CP04

Recombinant Human Tumor Necrosis Factor Receptor I/TNFRSF1A/CD120a (C-Fc)

SKU: CP04-10ug
$95.00Price
Size
Accession Number
Q9H7C4
Endotoxin
Species
Expression System
Less than 0.1 ng/ug (1 EU/ug)
Human
E. coli
Target Sequence
Tag
S168-P458
tag free
Formulation
Packaging
Supplied as a 0.2 um filtered solution of 10umM sodium phosphate, 30umM NaCl , 10% glycerol, pH 7.2
Dry ice/ice pack
Syncoilin intermediate filament 1; Syncoilin-1; SYNC1
Background
Alternative Names
Syncoilin (SYNC) is a muscle-specific intermediate filament protein that belongs to the intermediate filament family. The specific in vivo functions of syncoilin has not yet been determined, but it has been shown to be up-regulated at the sarcolemma in individuals with various forms of neuromuscular disease. Syncoilin is predicted to facilitate lateral force transmission during skeletal muscle contraction, while it does not form homofilaments nor heterofilaments with other IF proteins.
Accession Number
P10599
Endotoxin
Species
Expression System
Less than 0.1 ng/ug (1 EU/ug)
Human
E. coli
Target Sequence
Tag
M1-V105
C-Avi&6His
Formulation
Packaging
Lyophilized frum a 0.2 um filtered solution of 2umM Na2HPO4, 2umM NaH2PO4, pH7.4.
Ambient
Thioredoxin1; Thioredoxin-1; Trx1; TXN; TXN1
Background
Alternative Names
Thioredoxin (TXN) is a small ubiquitous protein in all cells that plays an important role in cellular redox reactions. It is secreted by lymphocytes, hepatocytes, fibroblasts, and several tumor cells. TXN is up-regulated under stress conditions such as hypoxia, elevated hydrogen peroxide concentrations, photochemical oxidative stress, and viral and bacterial infections. TXN modulates the growth factor activities, and the antioxidant properties, as well as act as a cofactor that provides reducing equivalents, and transcriptional regulation.
Accession Number
P23919
Endotoxin
Species
Expression System
Less than 0.1 ng/ug (1 EU/ug)
Human
E. coli
Target Sequence
Tag
M1-K212
N-6His
Formulation
Packaging
Supplied as a 0.2 um filtered solution of 2umM PB, 15umM NaCl, pH7.4
Dry ice/ice pack
Thymidylate kinase;dTMP kinase;DTYMK;CDC8; TMPK; TYMK
Background
Alternative Names
Thymidylate kinase (DTYMK) is a member of the thymidylate kinase family. It is ubiquitously expressed in the liver and other tissues. DTYMK plays an essential role in dTTP synthesis pathway for DNA synthesis. It is involved in the pyrimidine metabolism and dTTP biosynthesis pathway. DTYMK catalyzes the conversion of dTMP to dTDP.
Accession Number
P30530
Endotoxin
Species
Expression System
Less than 0.1 EU/ug
Human
Human 293 Cells
Target Sequence
Tag
A26-P449
C-8His
Formulation
Packaging
Supplied as a 0.2 um filtered solution of PBS, pH7.2
Dry ice/ice pack
AXL oncogene; AXL; UFO
Background
Alternative Names
Tyrosine-protein kinase receptor UFO, also known as AXL receptor tyrosine kinase, is a member of protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL is highly expressed in metastatic colon tumors, while only weakly expressed in normal colon tissue. AXL functions in dampening the immune response, mediating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. It is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. AXL also plays a role in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thereby implicated in the stimulation of cell proliferation.
Accession Number
P63146
Endotoxin
Species
Expression System
Less than 0.1 ng/ug (1 EU/ug)
Human
E. coli
Target Sequence
Tag
Met1-Ser152
tag free
Formulation
Packaging
Supplied as a 0.2 um filtered solution of 10mM HEPES, pH 7.5
Dry ice/ice pack
Ubiquitin-Conjugating Enzyme E2 B; RAD6 Homolog B; HR6B; hHR6B; Ubiquitin Carrier Protein B; Ubiquitin-Conjugating Enzyme E2-17 kDa; Ubiquitin-Protein Ligase B; UBE2B; RAD6B
Background
Alternative Names
Ubiquitin-Conjugating Enzyme E2 B (UBE2B) is a member of the ubiquitin-conjugating enzyme family. UBE2B can be found in the nucleus and cytoplasm and is highly expressed in the brain, heart, and testis. UBE2B can catalyze the covalent attachment of ubiquitin to other proteins, and is essential for the multi-ubiquitination and degradation of N-end rule substrates. UBE2B is indispensability for postreplication repair of UV-damaged DNA and may be involved in neurite outgrowth. Moreover, UBE2B may have a role in sepsis-induced muscle protein proteolysis and cancer-induced cachexia. UBE2B is overexpressed in mouse and human breast cancer cell lines and tumors and has been reported to provide resistance to chemotherapy drugs.
Accession Number
O00526
Endotoxin
Species
Expression System
Less than 0.1 EU/ug
Human
Human Cells
Target Sequence
Tag
Asp26-Gly155
C-6His
Formulation
Packaging
Supplied as a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4
Dry ice/ice pack
Uroplakin-2; UP2; Uroplakin II; UPII; UPK2
Background
Alternative Names
Uroplakin-2 is a single-pass type I membrane protein that belongs to the uroplakin-2 family. Uroplakin-2 is a component of the asymmetric unit membrane (AUM) and expressed in the ureter, a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. Uroplakin-2 forms heterodimer with UPK1A that is necessary for exiting out of the endoplasmic reticulum (ER). Uroplakin-2 may play an important role in regulating the assembly of the AUM. AUM is believed to strengthen the urothelium by preventing cell rupture during bladder distention.
Accession Number
Q96N20
Endotoxin
Species
Expression System
Less than 0.1 ng/ug (1 EU/ug)
Human
E. coli
Target Sequence
Tag
S58-K162
N-6His
Formulation
Packaging
Lyophilized frum a 0.2 um filtered solution of 2umM PB, 15umM NaCl, pH7.4
Ambient
Zinc Finger Protein 75A; ZNF75A
Background
Alternative Names
Zinc finger protein 75A (ZNF75A) is a member of the krueppel C2H2-type zinc-finger protein family. It is widely expressed in oviduct epithelium and 190 other tissues. Zinc-finger proteins (ZFNs) play a role in several cellular processes through different molecular mechanisms. ZFN is involved in the development and differentiation of several tissues. It is also associated with tumorigenesis, cancer progression and metastasis formation.
Accession Number
O95229
Endotoxin
Species
Expression System
Less than 0.1 ng/ug (1 EU/ug)
Human
E. coli
Target Sequence
Tag
M1-P277
N-6His
Formulation
Packaging
Lyophilized frum a 0.2 um filtered solution of 2umM PB, 15umM NaCl, pH 7.2
Ambient
ZW10 Interactor; ZW10‐Interacting Protein 1; Zwint­‐1; ZWINT
Background
Alternative Names
ZW10 Interactor is localized to the kinetochores from late Prophase to Anaphase and has a uniform distribution in the cytoplasm of Interphase cells. ZWINT interacts ZW10, MIS12 and NDC80 subunit of the NDC80 complex specifically during mitosis. ZWINT is a part of the MIS12 complex which is required for kinetochore formation and spindle checkpoint activity. In addition, ZWINT is required to target ZW10 to the kinetochore at prometaphase.
Accession Number
Q00609
Endotoxin
Species
Expression System
Less than 0.1 EU/ug
Mouse
Human 293 Cells
Target Sequence
Tag
Val38-Asn246
C-His
Formulation
Packaging
Lyophilized frum a 0.2 um filtered solution of PBS, pH7.4
Ambient
T-lymphocyte activation antigen CD80; Activation B7-1 antigen; B7; CD80
Background
Alternative Names
CD80, also known as B7-1, is a member of cell surface immunoglobulin superfamily. CD80 is predominately expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. CD80 and CD86, together with their receptors CD28 and CTLA4, form one of the dominant co-stimulatory pathways that mediate T- and B- cell responses. Although both CD28 and CTLA4 can bind to CD80 and CD86, CTLA-4 has 20-100 fold higher affinity than CD28 plays a role in the down-regulation of the immune response. CD80 is also involved in the induction of innate immune responses by activating NF-?B-signaling pathway in macrophages. Therefore, CD80 has the potential to be promising therapeutic targets for autoimmune diseases and various carcinomas.
Accession Number
P42082
Endotoxin
Species
Expression System
Less than 0.1 EU/ug
Mouse
Human 293 Cells
Target Sequence
Tag
Val24-Lys244
C-His
Formulation
Packaging
Lyophilized frum a 0.2 um filtered solution of PBS, pH7.4
Ambient
T-lymphocyte activation antigen CD86; Activation B7-2 antigen; Early T-cell costimulatorymolecule 1; ETC-1; CD86
Background
Alternative Names
T-lymphocyte activation antigen CD86 (B7-2) is a type I membrane protein that belongs to the B7 family. CD86 is highly expressed on activated antigen presenting cells. CD86 plays an essential role for T-lymphocyte proliferation and interleukin-2 production through binding CD28 or CTLA-4. It is also involved in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Additionally, the CD86 participates innate immune responses by activating NF-?B-signaling pathway in macrophages. CD86 thus is predicted to be a promising candidate for immune therapy.
Accession Number
P01580
Endotoxin
Species
Expression System
Less than 0.1 EU/ug
Mouse
Human 293 Cells
Target Sequence
Tag
H23-C155
C-8His
Formulation
Packaging
Lyophilized frum a 0.2 um filtered solution of PBS, pH7.4
Ambient
Ifng;Interferon gamma;IFN-gamma
Background
Alternative Names
Mouse Interferon-gamma (IFN-?/IFNG) is a secreted protein that belongs to the type II (gamma) interferon family. IFNG is primarily expressed by T lymphocytes, and activated by specific antigens or mitogens. In addition to having antiviral activity, IFNG also has important immunoregulatory functions. It is a potent activator of macrophages and has antiproliferative effects on transformed cells as well as enhance the antitumor effects of the type I interferons. IFNG also functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation. The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis.
Accession Number
Q9ES17
Endotoxin
Species
Expression System
Less than 0.1 EU/ug
Mouse
Human 293 Cells
Target Sequence
Tag
H18-S146
tag free
Formulation
Packaging
Lyophilized frum a 0.2 um filtered solution of PBS, pH7.4
Ambient
Interleukin-21;Il21
Background
Alternative Names
Interleukin-21 (IL-21) is a cytokine that belongs to the IL-15 / IL-21 family. IL-21 is produced by CD4+ T cells in response to antigenic stimulation, facilitating the transition between innate and adaptive immunity. It induces the production of IgG1 and IgG3 in B-cells. IL-21 is also involved in the proliferation and maturation of natural killer cells in synergy with IL15. Dysregulation of IL-21 may be associated with multiple immune-mediated diseases.
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