Recombinant Human Tryptophan 5-Hydroxylase 2/TPH2 (N-6His)
SKU: CG32-10ug
$150.00Price
Recombinant Human Tryptophan 5-Hydroxylase 2 is produced by our E.coli expression system and the target gene encoding Met1-Ile496 is expressed with a 6His tag at the N-terminus. Bon Opus Cat. #CG32
Size
Accession Number
Q14CC5Background
Tryptophan 5-hydroxylase 2 (TPH2) is an isozyme member of the biopterin-dependent aromatic amino acid hydroxylase family. TPH2 is primarily expressed in the serotonergic neurons of the brain, with the highest expression found in the raphe nucleus of the midbrain. TPH2 catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD). Defects in TPH2 are the cause of psychiatric diseases such as bipolar affective disorder and major depression.Expression
E. coliPackaging
Dry ice/Polar packsFormulation
Supplied as a 0.2 μm filtered solution of 20mM PB，150mM NaCl,pH7.4.ALTnames
Tryptophan 5-Hydroxylase 2, Neuronal Tryptophan Hydroxylase, Tryptophan 5-Monooxygenase 2, TPH2, NTPH