Recombinant Human Tripartite Motif-Containing Protein 5/TRIM5/RNF88 (N-6His)

Recombinant Human Tripartite Motif-Containing Protein 5/TRIM5/RNF88 (N-6His)

SKU: CH37-10ug
Recombinant Human TRIM5 is produced by our E.coli expression system and the target gene encoding Met1-Gln248 is expressed with a 6His tag at the N-terminus. Bon Opus Cat. #CH37
  • Accession Number

  • Background

    Tripartite motif-containing Motif 5 is a protein that in humans is encoded by the TRIM5 gene.It is a 493 amino acids protein that belongs to the TRIM/RBCC family.It contains 1 B box-type zinc finger, 1 B30.2/SPRY domain and 1 RING-type zinc finger. TRIM5 present in the cytoplasm recognizes motifs within the capsid proteins and interferes with the uncoating process, therefore preventing successful reverse transcription and transport to the nucleus of the viral genome. The exact mechanism of action has not been shown conclusively, but capsid protein from restricted viruses is removed by proteasome-dependent degradation
  • Expression

    E. coli
  • Packaging

    Dry ice/Polar packs
  • Formulation

    Supplied as a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
  • ALTnames

    Tripartite motif-containing protein 5,RING finger protein 88,TRIM5,RNF88
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