Recombinant Human TREM-1 (C-His)

TREM1 (triggering receptor expressed on myeloid cells) is a type I transmembrane protein with a single Ig-like domain. TREM1 is expressed on blood neutrophils and monocytes, and the expression is up-regulated by bacterial LPS. Although its natural ligand has not been found, engagement of TREM1 with agonist mAbs triggers secretion of the proinflammatory cytokines TNF-α and IL-1β, as well as chemokines such as IL-8 and monocyte chemoattractant protein (MCP)-1. TREM-1 is expressed at high levels on neutrophils of patients with microbial sepsis and in mice with a TREM-1/Fc fusion protein protected mice against LPS-induced shock. It has been demonstrated that TREM1 plays an important role in immune responses involved in host defense against microbial challenges, and is suggested to be a potential therapeutic target for septic shock.