Recombinant Human TRAIL/TNFSF10/CD253 (Val114-Gly281, C-6His)

Recombinant Human TRAIL/TNFSF10/CD253 (Val114-Gly281, C-6His)

SKU: CG92-10ug
Recombinant Human TNF-related Apoptosis-inducing Ligand is produced by our E.coli expression system and the target gene encoding Val114-Gly281 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CG92
  • Accession Number

  • Background

    Human TNFSF10 is a type II transmembrane protein with an intracellular N-terminus and a ‘TNF homology domain’ (THD) at the extracellular C terminus. TNFSF10 can interact with several distinct receptors. Two of these receptors that belongs to TNFR superfamily, DR4 (TRAIL-R1) and DR5 (TRAIL-R2/TRICK2), are plasma membrane proteins containing intracellular death domains essential for activating apoptosis. TNFSF10 is promising for cancer therapy because it is cytotoxic and activates apoptosis in the majority of malignant cells, but not in normal cells.
  • Expression

    E. coli
  • Packaging

  • Formulation

    Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
  • ALTnames

    Tumor Necrosis Factor Ligand Superfamily Member 10, Apo-2 Ligand, Apo-2L, TNF-Related Apoptosis-Inducing Ligand, Protein TRAIL, CD253, TNFSF10, APO2L, TRAIL
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