Recombinant Human Thimet Oligopeptidase/THOP1 (C-6His)
SKU: C179-10ug
$150.00Price
Recombinant Human Thimet Oligopeptidase is produced by our E.coli expression system and the target gene encoding Lys2-Cys689 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #C179
Size
Accession Number
P52888Background
Thimet Oligopeptidase (THOP1) belongs to the peptidase M3 family which includes neurolysin and mitochondrial intermediate peptidase. THOP1 is located in Cytoplasm. THOP1 is widely expressed in human tissues and can detected in different subcellular locations. THOP1 is preferential cleavage for bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues. THOP1 is involved in the metabolism of neuropeptides under 20 amino acid residues and degradation of cytoplasmic peptide. In addition, THOP1 also can degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.Expression
E. coliPackaging
Dry ice/Polar packsFormulation
Supplied as a 0.2 μm filtered solution of 20mM PB, 100mM NaCl, 10% Glycerol, pH 7.0.ALTnames
Thimet Oligopeptidase, Endopeptidase 24.15, MP78, THOP1