Recombinant Human Sulfamidase/SGSH (C-His)

Recombinant Human Sulfamidase/SGSH (C-His)

SKU: BP124-50ug
Recombinant Human N-Sulphoglucosamine Sulphohydrolase is produced by our Mammalian expression system and the target gene encoding Arg21-Leu502 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #BP124
  • Accession Number

  • Expression

    Human 293 Cells
  • Packaging

    Dry ice/ice pack
  • Formulation

    Supplied as a 0.2 um filtered solution of 20mM TrisHCl,150mM NaCl,1mM GaCl2,10%Glycerol,pH7.5.
  • Background

    N-Sulphoglucosamine Sulphohydrolase (SGSH) is a member of the sulfatase family that is involved in the degradation of heparin sulfate (HS). SGSH catalyzes N-sulfo-D-glucosamine and H2O to D-glucosamine and sulfate. Unlike the HS specific endosulfatases that remove sulfate from internal GlcNAc residues, SGSH removes sulfate group from the non-reducing end glucosamine residues on HS. SGSH leads to mucopolysaccharidosis type 3A (MPS3A), a recessive lysosomal storage disease characterized by neurological dysfunction but relatively mild somatic manifestations.
  • ALTnames

    N-Sulphoglucosamine Sulphohydrolase; Sulfoglucosamine Sulfamidase; Sulphamidase; SGSH; HSS
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