Recombinant Human Sulfamidase/SGSH (C-His)
Recombinant Human N-Sulphoglucosamine Sulphohydrolase is produced by our Mammalian expression system and the target gene encoding Arg21-Leu502 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #BP124
ExpressionHuman 293 Cells
PackagingDry ice/ice pack
FormulationSupplied as a 0.2 um filtered solution of 20mM TrisHCl,150mM NaCl,1mM GaCl2,10%Glycerol,pH7.5.
BackgroundN-Sulphoglucosamine Sulphohydrolase (SGSH) is a member of the sulfatase family that is involved in the degradation of heparin sulfate (HS). SGSH catalyzes N-sulfo-D-glucosamine and H2O to D-glucosamine and sulfate. Unlike the HS specific endosulfatases that remove sulfate from internal GlcNAc residues, SGSH removes sulfate group from the non-reducing end glucosamine residues on HS. SGSH leads to mucopolysaccharidosis type 3A (MPS3A), a recessive lysosomal storage disease characterized by neurological dysfunction but relatively mild somatic manifestations.
ALTnamesN-Sulphoglucosamine Sulphohydrolase; Sulfoglucosamine Sulfamidase; Sulphamidase; SGSH; HSS