Recombinant Human Sialic acid-binding lectin/CD33 antigen-like 3/CD33L3
Recombinant Human Siglec-15 is produced by our Mammalian expression system and the target gene encoding Phe19-Thr263 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CW37
BackgroundHuman Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO-terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type Ig domains which have no binding activity. Siglecs differ in the number of these C2-type domains. Human Siglec-15 consists of a 244 amino acid (aa) extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 function is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts
FormulationLyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
ALTnamesSialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3