BackgroundSmall Glutamine-Rich Tetratricopeptide Repeat-Containing Protein α (SGTA) is an ubiquitously expressed protein which belongs to the SGT Family. SGTA contains three TPR Protein-Protein Interaction Duplicates. SGTA is a co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. SGTA is capable of interacting with the major nonstructural protein of Parvovirus H-1 and 70-kDa heat shock cognate protein. It interacts with NS1 from Parvovirus H-1, with Vpu and Gag from HIV-1. It also interacts with SARS-CoV Accessory Protein 7a, DNAJC5 and DNAJC5B. However, its function is not known. Since this transcript is expressed ubiquitously in various tissues, SGTA may serve a housekeeping function.
FormulationLyophilized from a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, pH 8.0.
ALTnamesSmall Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha, Alpha-SGT, Vpu-Binding Protein, UBP, SGTA, SGT, SGT1