Recombinant Human S100 Calcium Binding Protein S100A8/S100A9 Heterodimer (C-His)
Recombinant Human S100A8/S100A9 Heterodimer is produced by E.coli. The target gene encoding M1-E93 & M1-P114 is expressed with a 6His tag at the C terminus.
P05109 & P06702
BackgroundS100A8 and S100A9 are pro-inflammatory members of the S100 family of secreted calcium binding proteins. They are produced by neutrophils and monocytes, and forms Ca2+-dependent heterodimer/heterotetramer complexes (known as calprotectin). Calprotectin (S100A8/A9) is upregulated at sites of inflammation (e.g. psoriasis, rheumatoid arthritis, cardiac ischemia). It is involved in facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase.
FormulationSupplied as a 0.2 um filtered solution of 2umM HEPES, 15umM NaCl, 10% Glycerol, 2.umM EDTA, pH7.4.
PackagingDry ice/ice pack