(800) 943-6396

150 Essex St, Millburn, NJ 07041, USA

©2019 by Bon Opus Biosciences, LLC.

Recombinant Human Receptor Tyrosine-Protein Kinase ErbB-2/HER2 (C-Fc)

SKU: CX68-10ug
$95.00Price
Recombinant Human ErbB2 is produced by our Mammalian expression system and the target gene encoding Thr23-Thr652 is expressed with a Fc tag at the C-terminus. Bon Opus Cat. #CX68
Size
  • Accession Number

    P04626
  • Background

    Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and differentiation. HER2 has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. HER2 is activated by dimerization and not activated by EGF, TGF-alpha and amphiregulin. Interaction with PTK6 increases its intrinsic kinase activity.It is heterodimer with EGFR, ERBB3 and ERBB4. HER2 associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. It implicated in transcriptional activation of CDKN1A and the function of the protein involves STAT3 and SRC. And also it involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
  • Expression

    Human Cells
  • Packaging

    Ambient
  • Formulation

    Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
  • ALTnames

    Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, Proto-oncogene Neu,Tyrosine kinase-type cell surface receptor HER2, ERBB2,MLN19,NGL,TKR1