Recombinant Human Proprotein Convertase 9 is produced by our Mammalian expression system and the target gene encoding Gln31-Gln692 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CA83

Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9/PCSK9 (C-6His)

Name: Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9/PCSK9 (C-6His)
SKU: CA83-10ug

SKU: CA83-10ug

$110.00

Quantity

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Email: orders@bonopusbio.com

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Shipping Information

$48 Standard Overnight flat rate for products shipped in room temperature within the United States.

Additional $27 Ice Packs shipment fee is required for liquid proteins.

Please contact us to order for international shipments.

Certificate of Analysis

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Endotoxin

Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

Accession Number

Q8NBP7

Species

Human

Expression System

Human Cells

Target Sequence

Gln31-Gln692

C-His

Formulation

Supplied as a 0.2 um filtered solution of 50mM HEPES, 150mM NaCl, 20% Glycerol, pH 7.4.

Packaging

Dry Ice/ice packs

Background

Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Proprotein Convertase Subtilisin/Kexin Type 9; Neural Apoptosis-Regulated Convertase 1; NARC-1; Proprotein Convertase 9; PC9; Subtilisin/Kexin-Like Protease PC9; PCSK9; NARC1