BackgroundProgonadoliberin-2, also known as Progonadoliberin II and GNRH2, belongs to the gonadotropin-releasing hormone family. GNRH2 is specially expressed in midbrain, at significantly higher levels outside the brain (up to 30-fold). GNRH2 can be cleaved into two chains, gonadoliberin-2 and GnRH-associated peptide 2. gonadoliberin-2 regulates reproduction in females by stimulating the secretion of both luteinizing- and follicle-stimulating hormones. The proproteins produce three transcript variants, but produce the same peptide hormone.
FormulationLyophilized from a 0.2 μm filtered solution of PBS,PH7.4.
ALTnamesProgonadoliberin-2, Progonadoliberin II, Gonadoliberin-2, Gonadoliberin II, Gonadotropin-Releasing Hormone II, GnRH II, Luliberin II, Luteinizing Hormone-Releasing Hormone II, LH-RH II, GnRH-Associated Peptide 2, GnRH-Associated Peptide II, GNRH2