BackgroundPrefoldin Subunit 2 (PFDN2) belongs to the Prefoldin Beta subunit family. The PFDN2 protein is one of six subunits of Prefoldin that act as a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. PFDN2 binds specifically to Cytosolic Chaperonin (c-CPN) and transfers target proteins to it. PFDN2 also binds to a nascent polypeptide chain and promotes folding in settings where there are many competing pathways for non-native proteins.
FormulationLyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 50mM NaCl, 1mM DTT, pH 8.0.
ALTnamesPrefoldin Subunit 2, PFDN2, PFD2