Recombinant Human PPIase B/PPIB(C-6His)

Cyclophilin B is a member of the cyclophilin-type PPIase family and PPIase B subfamily which contains one PPIase cyclophilin-type domain. Cyclophilin B is a cyclosporin A binding protein that can be secreted in response to inflammatory stimuli. Cyclophilin B interaction with prolactin potentiated prolactin-induced proliferation, cell growth, and the nuclear retrotransport of prolactin. The intranuclear prolactin/cyclophilin B complex acts as a transcriptional inducer by interacting directly with Stat5, resulting in the removal of the Stat-repressor protein inhibitor of activated Stat 3 (PIAS3), thereby enhancing Stat5 DNA-binding activity and prolactin-induced, Stat5-mediated gene expression. Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9).