Recombinant Human Platelet-derived Growth Factor Receptor/PDGF Rα (C-6His)
Recombinant Human Platelet-derived Growth Factor Receptor Alpha is produced by our Mammalian expression system and the target gene encoding Gln24-Glu524 is expressed with a 6His at the C-terminus. Bon Opus Cat. #C658
BackgroundPlatelet-derived Growth Factor Receptor Alpha (PDGF Rα) is an enzyme that belongs to the class III subfamily of receptor tyrosine kinases.It is a type I transmembrane glycoprotein, and can form homo- or hetero-dimeric receptors when engaged by dimers of the PDGF family of growth factors, PDGF Rα is strongly expressed in oligodendrocyte, lung, skin and intestinal progenitor cells and induced by inflammation or growth in culture, but is lowly expressed in most mesenchymal cells. PDGF Rα autophosphorylates upon dimerization, activating signaling cascades in PI-3kinase Ras-MAP kinase, and PLC-γ pathways. PDGF Rα has infulence on local gradients of epithelially produced PDGF-AA or PDGF-CC during formation of the cranial ,cardiac neural crest and interstitial kidney mesenchyme.
FormulationLyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
ALTnamesPlatelet-derived growth factor receptor alpha; PDGFR-alpha; Alpha platelet-derived growth factor receptor;CD140 antigen-like family member A; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 2; PDGFR-2; CD140a