Recombinant Human PAPS Synthase 1/PAPSS1 (C-6His)

Recombinant Human PAPS Synthase 1/PAPSS1 (C-6His)

SKU: CI62-10ug
Recombinant Human PAPS synthase 1 is produced by our Mammalian expression system and the target gene encoding Met1-Ala624 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CI62
  • Accession Number

  • Background

    PAPSS1 is a bifunctional enzyme with both ATP sulfurylase and APS kinase activity. In the N-terminal section, it belongs to the APS kinase family; while the C-terminal section belongs to the sulfate adenylyltransferase family. PAPSS1 can be inhibited by chlorate, and is expressed in many tissues, such as high endothelial venules (HEV) cells and in cartilage. PAPSS1 mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate. In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. PAPSS1 also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.
  • Expression

    Human Cells
  • Packaging

    Dry ice/Polar packs
  • Formulation

    Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl and 20% glycerol.
  • ALTnames

    Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1,PAPS synthase 1,PAPSS 1,Sulfurylase kinase 1,SK 1,ATPSK1, PAPSS
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