Recombinant Human Oncostatin-M-Specific Receptor Subunit/OSMRB/IL-31RB (C-6His)
Recombinant Human OSM receptor beta is produced by our Mammalian expression system and the target gene encoding Glu28-Ser739 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #C496
BackgroundOncostatin-M-Specific Receptor Subunit β (OSMRβ) is a 150 - 180 kDa member of the IL-6 receptor family. OSMRβ associates with gp130 to form the type II OSM receptor, the receptor is responsive to OSM. Gp130 subunit is shared by other IL-6 family cytokine receptors, and OSMRβ associates with gp130-like receptor (GPL) to form a receptor complex responsive to IL-31. The human OSMRβ cDNA encodes a 979 amino acid (aa) precursor, the precursor includes a 27 aa signal sequence, a 712 aa extracellular domain (ECD), a 22 aatransmembrane segment, and a 218 aa cytoplasmic domain. The ECD contains one partial and one complete hematopoietin domain, an Ig-like domain, and three Fibronectin type-III domains.
FormulationLyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
ALTnamesOncostatin-M-Specific Receptor Subunit Beta, Interleukin-31 Receptor Subunit Beta, IL-31 Receptor Subunit Beta, IL-31R Subunit Beta, IL-31R-Beta, IL-31RB, OSMR, OSMRB