Recombinant Human NKG2-A/NKG2-B Type II Integral Membrane Protein(N-His)

NKG2-A/NKG2-B is a type II integral membrane protein that contains one C-type lectin domain and belongs to the killer cell lectin-like receptor family. This family consists of transmembrane proteins expressed mainly in NK cells and characterized by type II membrane orientation and a C-type lectin domain. NKG2 is exclusively expressed in NK cells, not T or B cells. Studies have shown that NKG2 is a family of related cDNA clones, including NKG2A, NKG2B, NKG2C, and NKG2D, encoding type II integral membrane proteins with a C-type lectin domain at the extracellular C-terminus. NKG2 acts as a receptor for MHC class I HLA-E molecules, recognized by NK cells and some cytotoxic T cells. NKG2A and NKG2B are designated CD159a in the CD antigen nomenclature. Increased expression of NKG2A in tumor-infiltrating NK cells is emerging as a contributor to determining the poor prognosis of hepatocellular, lung, or other carcinomas and may be a predictive factor for tumor metastasis.