Recombinant Human Neural Cell Adhesion Molecule 1/NCAM-1/CD56 (C-6His)
Recombinant Human Neural cell adhesion molecule 1 is produced by our expression system and the target gene encoding Leu20-Pro603 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CP45
BackgroundNeural cell adhesion molecule 1 (NCAM-1) is a single-pass type I membrane protein, it belongs to a family of membrane-bound glycoproteins that are involved in Ca2+ independent cell matrix and homophilic or heterophilic cell-cell interactions. NCAM-1 is synthesized as a 761 aa preproprecursor that contains a 19 aa signal sequence, a 722 aa GPI-linked mature region, and a 20 aa C-terminal prosegment. The molecule contains five C-2 type Ig-like domains and two fibronectin type-III domains. NCAM-1 is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Acting as a receptor for rabies virus, NCAM-1 in the adult brain shows a decline of sialylation relative to earlier developmental periods.
FormulationLyophilized from a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, pH8.0.
ALTnamesCD56; NCAM-1; CD56 antigen; MSK39; N-CAM-1; NCAM-1; neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM