Recombinant Human Natural Killer G2D is produced by our Mammalian expression system and the target gene encoding Phe78-Val216 is expressed with a Fc tag at the N-terminus. Bon Opus Cat. #CU41

Recombinant Human Natural Killer G2D/NKG2D/CD314/KLRK1 (N-Fc)

Name: Recombinant Human Natural Killer G2D/NKG2D/CD314/KLRK1 (N-Fc)
SKU: CU41-10ug

SKU: CU41-10ug

$95.00

Quantity

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Shipping Information

$48 Standard Overnight flat rate for products shipped in room temperature within the United States.

Additional $27 Ice Packs shipment fee is required for liquid proteins.

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Certificate of Analysis

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Endotoxin

Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

Accession Number

P26718

Species

Human

Expression System

Human Cells

Target Sequence

Phe78-Val216

N-Fc

Formulation

Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.

Packaging

Ambient

Background

NKG2-D type II integral membrane protein (NKG2D) is a type II transmembrane glycoprotein which belongs to the CD94/NKG2 family. NKG2D is expressed on natural killer (NK) cells, CD8+ alpha-beta and gamma-delta T-cells. As an activating and costimulatory receptor, it involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. It provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. It stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. NKG2D participates in NK cell-mediated bone marrow graft rejection and survival of NK cells. It Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.