Recombinant Human MHC Class I Polypeptide-Related Sequence A/MICA (C-Fc)

Recombinant Human MHC Class I Polypeptide-Related Sequence A/MICA (C-Fc)

SKU: CG11-10ug
Recombinant Human MHC Class I-related Protein A is produced by our Mammalian expression system and the target gene encoding Ala23-Glu308 is expressed with a Fc tag at the C-terminus. Bon Opus Cat. #CG11
  • Accession Number

  • Background

    MHC class I polypeptide-related sequence A, also known as MIC-A, PERB11.1 and MICA, is a single-pass type I membrane protein which belongs to the MHC class I family of MIC subfamily. MICA contains one Ig-like C1-type domain and is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by NK cells, NKT cells, and most of the subtypes of T cells. MICA is the ligand for NK cell activating receptor KLRK1/NKG2D. MICA seems to have no role in antigen presentation. MICA leads to cell lysis by binding to KLRK1.
  • Expression

    Human Cells
  • Packaging

  • Formulation

    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
  • ALTnames

    MHC Class I Polypeptide-Related Sequence A, MIC-A, MICA, PERB11.1
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