BackgroundKiller-Cell Immunoglobulin-Like Receptors (KIRs) are important cells of the immune system. KIRs are a family of Natural Killer (NK) Cells surface glycoproteins. KIRs control the killing function of these cells by interacting with MHC class I molecules. This interaction allows KIRs to identify virally infected cells or tumor cells by the distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. KIR2DL3 is an inhibitory Killer Cell Ig-like Receptor. KIR2DL3 recognizes class I MHC molecules (HLA-Cw1, -Cw3, -Cw7, and Cw8). KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.
FormulationLyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
ALTnamesKiller Cell Immunoglobulin-Like Receptor 2DL3, CD158 Antigen-Like Family Member B2, KIR-023GB, Killer Inhibitory Receptor cl 2-3, MHC Class I NK Cell Receptor, NKAT2a, NKAT2b, Natural Killer-Associated Transcript 2, NKAT-2, p58 Natural Killer Cell Receptor Clone CL-6, p58 NK Receptor CL-6, p58.2 MHC Class-I-Specific NK Receptor, CD158b2, KIR2DL3, CD158B2, KIRCL23, NKAT2