Recombinant Human Kallikrein 2/KLK2 (C-6His)
Recombinant Human Kallikrein 2 is produced by our Mammalian expression system and the target gene encoding Pro19-Pro261 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #C616
BackgroundKallikrein-2 (KLK2) is a secreted serine protease that belongs to the peptidase S1 family of Kallikrein subfamily. KLK2 contains 1 peptidase S1 domain. It is highly expressed in the human prostate gland. KLK2 can cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin, but Preferential cleavages of Arg-|-Xaa bonds in small molecule substrates. It also highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa. KLK2 is inhibited by serpins such as protein C inhibitor, antichymotrypsin, and plasminogen. KLK2 is considered to be a biomarker for prostate cancer.
PackagingDry ice/Polar packs
FormulationSupplied as a 0.2 μm filtered solution of 20mM Citrate, 150mM NaCl, pH 3.5.
ALTnamesKallikrein-2; Glandular Kallikrein-1; hGK-1; Tissue Kallikrein-2; KLK2