Recombinant Human Interleukin-7/IL-7 (C-His)

Recombinant Human Interleukin-7/IL-7 (C-His)

SKU: BP086-50ug
Recombinant Human Interleukin-7 is produced by Human 293 Cells. The target gene encoding D26-H177 is expressed with a 6His tag at the C terminus.
  • Accession Number

  • Expression

    Human 293 Cells
  • Background

    Interleukin 7 (IL-7) is a cytokine that belongs to hemopoietin family. IL-7 is secreted by stromal cells in the red marrow and thymus, and can also be produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells, except for lymphocytes. IL-7 stimulates the differentiation of multipotent hematopoietic stem cells into lymphoid progenitor cells. It also induces the proliferation of all cells in the lymphoid lineage (B cells, T cells and NK cells). IL-7 and the hepatocyte growth factor (HGF) together form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction. IL-7 has recently been examined in clinical studies as an immunotherapy agent for various malignancies and during HIV infection. Besides, IL-7 could be beneficial in improving immune recovery after allogenic stem cell transplant.
  • Formulation

    Lyophilized frum a 0.2 um filtered solution of PBS, pH7.4
  • Packaging

  • ALTnames

    Interleukin-7; IL-7; IL7

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