Recombinant Human Interferon Lambda-2/IL-28A(C-6His)
Recombinant Human Interferon Lambda-2 is produced by our Mammalian expression system and the target gene encoding Val26-Val200 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CS36
BackgroundIL-28A (Interferon-λ2 IFN-λ2), IL-28B/IFN-λ3, and IL-29/IFN-λ1 are type III interferons which are distantly related to IL-10 family and type I IFN family cytokines. Mature human IL-28A is an approximately 22-25 kDa protein that shares 66% amino acid (aa) sequence identity with mouse and rat IL-28A and shows cross-species activity. It shares 96% and 70% aa sequence identity with human IL-28B and IL-29, respectively. IL-28A promotes the Th1 polarization of dendritic cells in the airway and inhibits Th2 and Th17 mediated inflammation. IL-28A additionally exhibits anti-tumor activity, in part by enhancing IL-12 dependent anti-tumor CTL responses in vivo. In contrast, it is up-regulated in invasive bladder cancer where it promotes tumor cell migration.
FormulationLyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
ALTnamesInterferon lambda-2; IFN-lambda-2; Cytokine Zcyto20; Interleukin-28A; IL-28A; IFNL2; IL28A; ZCYTO20