Recombinant Human Interleukin-23 is produced by our Mammalian expression system and the target gene encoding Ile23-Ser328&Ala21-Pro189 is expressed with a Fc tag at the C-terminus.
Recombinant Human IL-23 (C-Fc)
SKU: CW93-10ug
$146.00Price
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Shipping Information
$48 Standard Overnight flat rate for products shipped in room temperature within the United States.
Additional $27 Ice Packs shipment fee is required for liquid proteins.
Please contact us to order for international shipments.
Endotoxin
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Accession Number
P29460&Q9NPF7
Species
Human
Expression System
Mammalian
Target Sequence
Ile23-Ser328&Ala21-Pro189
Tag
C-Fc
Formulation
Lyophilized from a 0.2 um filtered solution of 20mMPB,150mMNaCl,pH7.4.
Packaging
Ambient
Background
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
SGRF;IL-23p19;CLMF p40;IL-12 subunit p40;NKSF2
Alternative Names
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Citation
Measured by its ability to induce STAT reporter activity in 293F human embryonic kidney cells.
Activity
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