Recombinant Human Interleukin-17 Receptor D is produced by our Mammalian expression system and the target gene encoding Cys17-Arg299 is expressed with a Fc tag at the C-terminus.
Recombinant Human IL-17RD/SEF (C-Fc)
SKU: C12R-10ug
$97.00Price
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Shipping Information
$48 Standard Overnight flat rate for products shipped in room temperature within the United States.
Additional $27 Ice Packs shipment fee is required for liquid proteins.
Please contact us to order for international shipments.
Endotoxin
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Accession Number
Q8NFM7
Species
Human
Expression System
Human Cells
Target Sequence
Cys17-Arg299
Tag
C-Fc
Formulation
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
Packaging
Ambient
Background
Interleukin-17 receptor D (IL-17 RD), also known as SEF (similar expression to FGFs), is a type I transmembrane protein that is found in both the cytoplasm and plasma membrane. IL-17RD functions as a feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. It may inhibit FGF-induced FGFR1 tyrosine phosphorylation, regulate the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK By similarity, and mediate JNK activation and may be involved in apoptosis. IL-17RD interacts with the IL-17R downstream molecule TRAF6. It has been proposed that the IL-17RD intracellular domain interacts with IL-17R and TRAF6 to deliver the downstream signal.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
IL-17 RD; IL17RD; IL-17RD; IL-17RDIL-17 receptor D; IL17Rhom; IL17RLM; interleukin 17 receptor D; SEF
Alternative Names
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Citation
NA
Activity
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