Recombinant Human Heat Shock Protein beta-11 is produced by our E.coli expression system and the target gene encoding Met1-Ser144 is expressed with a 6His tag at the N-terminus. Bon Opus Cat. #C251

Recombinant Human Heat Shock Protein β-11/HSPB11 (N-6His)

Name: Recombinant Human Heat Shock Protein β-11/HSPB11 (N-6His)
SKU: C251-10ug
Price: 158 USD
Availability: InStock

SKU: C251-10ug

$158.00

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Quantity

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Phone: 800-943-6396 ext#1

Email: orders@bonopusbio.com

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Shipping Information

$48 Standard Overnight flat rate for products shipped in room temperature within the United States.

Additional $27 Ice Packs shipment fee is required for liquid proteins.

Please contact us to order for international shipments.

Certificate of Analysis

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Endotoxin

Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

Accession Number

Q9Y547

Species

Human

Expression System

E.coli

Target Sequence

Met1-Ser144

N-His

Formulation

Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 100mM NaCl, 2mM DTT, 10% Glycerol, pH 8.0.

Packaging

Dry ice/Polar packs

Background

Heat Shock Protein β-11 (HSPB11) is a stress-responsive protein that is required to deal with proteotoxic stresses. HSPB11 is composed of an IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20 and is detected in placenta. HSPB11 has beeb shown to form oligomeric complexes and prevent the aggregation of in vitro denaturated aldolase and glyceraldehyde-3-phosphate dehydrogenase in accordance with the chaperone model of HSPB1 and HSPB5. HSPB11 overexpression protected against etoposide-induced cell death that correlated with a decreased release of mitochondrial Cytochrome C into the cytosol. Inhibition of HSP90 function completely abrogated the protective effect of HSPB11. This data suggests that at least in the case of HSPB11, interaction with other chaperone machines besides HSPA1A may contribute to functional specificity and cellular functioning.