Recombinant Human Guanidinoacetate N-Methyltransferase/GAMT (N, C-6His)

Recombinant Human Guanidinoacetate N-Methyltransferase/GAMT (N, C-6His)

SKU: CG67-10ug
$95.00Price
Recombinant Human GAMT is produced by our E.coli expression system and the target gene encoding Met1-Gly236 is expressed with a 6His tag at the N-terminus, 6His tag at the C-terminus. Bon Opus Cat. #CG67
Size
  • Accession Number

    Q14353
  • Background

    GAMT is a methyltransferase which belongs to the class I-like SAM-binding methyltransferase superfamily. It contains one RMT2 (arginine N-methyltransferase 2-like) domain and is expressed in liver. GAMT converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in GAMT are the cause of guanidinoacetate methyltransferase deficiency, which is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of expressive and cognitive speech, intractable seizures and movement disturbances, severe depletion of creatine/phosphocreatine in the brain, and accumulation of guanidinoacetic acid in brain and body fluids.
  • Expression

    E. coli
  • Packaging

    Dry ice/Polar packs
  • Formulation

    Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,1mMDTT,pH 8.0 .
  • ALTnames

    Guanidinoacetate N-methyltransferase, GAMT, PIG2,TP53I2

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