Recombinant Human Grancalcin/GCA (N-GST)
Recombinant Human Grancalcin is produced by our E.coli expression system and the target gene encoding Met1-Ile217 is expressed with a GST tag at the N-terminus. Bon Opus Cat. #C144
BackgroundGrancalcin (GCA) is a member of the penta EF hand subfamily which includes sorcin, calpain and ALG2. Grancalcin is highly expressed bone marrow and also can detected in neutrophils and macrophages. Grancalcin interacts with L-plastin which known to have actin bundling activity. It indicates that Grancalcin may play an important role in the adhesion of neutrophils to fibronectin. Furthermore, Grancalcin localization is dependent upon calcium and magnesium. It associates with both the granule and membrane fractions, which suggested a role for grancalcin in granule-membrane fusion and degranulation.
FormulationLyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 500mM Nacl, pH 8.5 .
ALTnamesGrancalcin, GCA, GCL