Recombinant Human Glypican-3 is produced by our Mammalian expression system and the target geneencoding Gln25-His559 is expressed with a 6His tag at the C-terminus.
Recombinant Human Glypican-3/GPC3 (C-His)
SKU: BP171-10ug
$95.00Price
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Shipping Information
$48 Standard Overnight flat rate for products shipped in room temperature within the United States.
Additional $27 Ice Packs shipment fee is required for liquid proteins.
Please contact us to order for international shipments.
Endotoxin
less than 0.1 ng/ug (1 EU/ug) as determined by TAL test.
Accession Number
P51654
Species
Human
Expression System
Human 293 Cells
Target Sequence
Gln25-His559
Tag
C-6His
Formulation
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4
Packaging
Ambient
Background
Glypican-3 (GPC3) is a heparan sulfate proteoglycan that belongs to the glypican family. GPC3 is highly expressed in lung, liver, and kidney. GPC3 is overexpressed in various neoplasms including hepatocellular carcinoma, malignant melanoma, and testicular yolk sac tumor, and plays an essential role in cell growth and differentiation. GPC3 has tissue-dependent function. In certain tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein. GPC3 expression has also been found in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary. The role of GPC3 in melanomas is still debated. Thus, GPC3 is currently considered as a tumor marker and potential target for immunotherapy.
Purity
greater than 95% as determined by reducing SDS-PAGE.
Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5
Alternative Names
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Citation
NA
Activity
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